![]() Ventilatory limitation can be due to underlying lung and/or pleural disease or from tumor involving the respiratory system itself. These symptoms may originate from ventilatory, cardiovascular, pulmonary vascular, and musculoskeletal causes. Patients with cancer commonly experience dyspnea and fatigue. Potentialįactors include effects of chemo- and radiation therapy on cardiac function and Source for exercise limitation with a prominent pulmonary vascular component. With malignancies exhibit dead space breathing, many exhibiting a circulatory Intercept of the V’ E -V’CO 2 relationship was lowest in Ventilatory cohorts, consistent with increase in dead space breathing. Peak V’ E / V’O 2 and V’ E /V’CO 2 were highest in the circulatory and There were close associations between V’O 2 and Pulmonary vascular group (n = 18) whose mean ± SD peak V’O 2 was 61 % ± 17% Results: Complete clinical and physiological data wereĪvailable for 36 patients (M/F 20/16) 32 (89%) exhibited ventilatory orĬirculatory limitation as shown by a reduced peak V’O 2 and 10 Peak V’O 2 <8 4 % predicted indicated a circulatory or ventilatory The slope and intercept for V’ E /V’CO 2 wasĬomputed for all subjects. Ventilatory equivalents for carbon dioxide and oxygen (V’ E /V’CO 2 and V’ E /V’O 2, respectively) were measured at baseline and Minute ventilation, heart rate,īreathing reserve, oxygen uptake (V’O 2 ), O 2 -pulse, Methods: Subjects were exercised onĪ cycle ergometer with increasing workloads. ![]() Objectives: In thisĮvaluated patients with hematologic and solid malignancies by CPET to determine Sources, and dyspnea is best determined byĬardiopulmonary exercise testing (CPET). Rationale: Patients with cancer commonly experience dyspnea originating from ventilatory, circulatory and musculoskeletal
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